Services

We are experts in clinical trial simulations with e-Campsis, our in-house developed PK/PD simulator. We have a specialized service to quickly integrate and qualify PK/PD models from literature or your own files into e-Campsis, enabling prompt and reliable simulations.

What is e-Campsis?

With e-Campsis you can:

  • Setup PK/PD simulations conveniently in a graphical user interface
  • Import model code and parameters from NONMEM
  • Easily define and compare different parameter scenarios
  • Run simulations and what-if scenarios live in a web browser and show it to your team
  • Post-process simulation results to derive, e.g. AUC, Cmax, % target attainment and show summary statistics in a table
  • Download the full simulation code as R-script for reproducible offline execution with our opensource packages campsis and campsismod

Model translation and implementation (MoTIS)

Do you have some model code from a previous project, a model database or a publication and want to quickly run simulations? Maybe you want to use a published model and adapt just a few parameters or change the dosing. However, you don’t have the time to translate your model into a specific simulation environment or write the whole thing from scratch in R. You also know that running, adapting and post-processing simulations with NONMEM can be quite inflexible and time-consuming.
At Calvagone we are specialized in efficiently implementing pharmacometric models into Campsis, our open-source simulation platform (https://calvagone.github.io/). You share with us the code or a publication describing the model and we will implement it in the e-Campsis user interface, ready for you to run simulations, explore dosing schedules and change parameter values. The clearly structured web interface of e-Campsis and the fast execution will allow you to show simulations live in team meetings and directly implement feedback from your colleagues in real-time. All implementations will be peer-reviewed by an experienced pharmacometrician and for NONMEM models you will even get a head-to-head qualification report, so you can be sure that the translation was accurate.

Simulation service

Of course, our service doesn’t stop with the implementation of the model in e-Campsis. If you need more help, we have ample experience in setting up sophisticated trial simulations and can support you with:

  • Dose-response simulations
  • Simulations to assess the probability of success
  • Simulation of dose-adaptations triggered by e.g. PD or AE events
  • Inter-species scaling of models and first-in-human simulations
  • Generation of forest plots with derived parameters such as Cmax, AUC or PD effect
  • Sensitivity analysis with visually appealing tornado plots as output
  • Scenario simulations to support best/worst-case decisions
  • Simulations of pediatric trials exploring weight-based dosing strategies
  • Clinical utility simulations
  • and much, much more…

Just drop us an e-mail requesting a call and we will get in touch with you ASAP to discuss your case.

Interested in using e-Campsis Pro in your organization?

Try the free version today – and contact us for a demo or a trial of the pro version.